Thursday, December 22, 2011

Mexico Disbands City's Police Force

VERACRUZ, Mexico (AP) - A Mexican state plagued by drug violence has disbanded the entire police force in the major port city of Veracruz, and officials say the Navy will take over.

The Veracruz state government says it's part of an effort to root out corruption from law enforcement and start from zero in the city of Veracruz.

State spokeswoman Gina Dominguez said Wednesday 800 police officers and 300 administrative employees were laid off. At a press conference, she said they can still apply for state police jobs but must meet stricter standards.

Armed marines have barricaded police headquarters and Navy helicopters were flying above the city where 35 bodies 35 bodies were dumped in September. It was one of the worst gang attacks of Mexico's drug war.

Source: http://www.myfoxny.com/dpps/news/international/mexico-disbands-entire-police-force-dpgapx-20111221-to_16527575

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Wednesday, December 7, 2011

EU seeks to save the euro, but S&P isn't convinced (AP)

PARIS ? Seeking to restore confidence in the euro, the leaders of France and Germany jointly have called for changes to the European Union treaty so that countries using the euro would face automatic penalties if budget deficits ran too high.

But not everyone on Wall Street was reassured that Europe would get control of its 2-year-old debt crisis.

Stock prices rose and borrowing costs for European governments dropped sharply in response to the changes proposed on Monday by French President Nikolas Sarkozy and German Chancellor Angela Merkel. But some of the optimism faded late in the day when Standard and Poor's threatened to cut its credit ratings on 15 eurozone countries, including the likes of Germany, France and Austria which have been considered Europe's safest government debt issuers.

The announcement came only hours after Sarkozy and Merkel revealed sweeping plans to change the EU treaty in an effort to keep tighter checks on overspending nations. The proposal is set to form the basis of discussions at a summit of EU leaders on Thursday and Friday that is expected to provide a blueprint for an exit from the crisis.

While the Franco-German plan would tie the 17-eurozone nations closer together, a tighter union would likely also result in heavier financial burdens for the region's stronger economies, which have already put up billions of euros to rescue Greece, Ireland and Portugal.

Analysts noted that the proposals did not foresee a clear roadmap on how to get the eurozone economies growing again and to reduce funding costs for struggling nations in the longterm.

"If this is all we get it's really very bad news for the future of the euro," said Simon Tilford, chief economist at London's Centre for European Reform.

Many analysts have called on the European Central Bank to intervene in debt markets to lower struggling countries' borrowing costs or the creation of eurobonds ? debt backed by all 17 euro countries.

"The onus is still on the ECB to print money to make huge loans or bond purchases and draw a line under the crisis," said Jennifer McKeown, senior European economist at Capital Economics.

The euro fell after the S&P announcement, trading down 0.1 percent at $1.339, and trading in futures on the S&P 500 and Dow Jones Industrial Average turned negative.

After the New York markets closed, S&P confirmed that it had placed 15 nations on notice for possible downgrades. Only two countries that use the euro weren't affected: Cyprus already had that designation and Greece already has ratings low enough to suggest that it's likely to default soon anyway.

France and Germany, the eurozone's two largest economies which currently both have an AAA-rating, quickly came out against the S&P move.

"Germany and France reaffirm that the proposals they made jointly today will reinforce the governance of the euro area in order to foster stability, competitiveness and growth," they said in a joint statement. "France and Germany, in full solidarity, confirm their determination to take all the necessary measures, in liaison with their partners and the European institutions to ensure the stability of the euro area."

Stocks had risen after the leaders of France and Germany called for a new treaty to impose greater fiscal discipline on European countries. Yields on Italian government bonds receded sharply after the new premier Mario Monti introduced sweeping austerity measures over the weekend. That suggests traders believe Italy is less likely to default.

Investors are hoping that the summit of European leaders on Thursday and Friday will produce concrete measures to prevent a messy breakup of the euro currency, which is shared by 17 nations. Markets have been jittery because of fears that the euro might disintegrate, causing a sharp recession in Europe that would spread through the world economy.

"Our wish is to go on a forced march toward re-establishing confidence in the eurozone," Sarkozy said at a news conference in Paris on Monday, with Merkel at his side. "We are conscious of the gravity of the situation and of the responsibility that rests on our shoulders."

EU treaty changes could take months, if not years, to implement and don't wipe away the mountains of government debt dragging down Europe's economy. But preliminary buy-in Friday from the 17 countries that use the euro could set the stage for further emergency aid from the European Central Bank, the International Monetary Fund or some combination.

"The onus is still on the ECB to print money to make huge loans or bond purchases and draw a line under the crisis," said Jennifer McKeown, senior European economist at Capital Economics. "Perhaps if other member states sign up to Merkel's and Sarkozy's proposals this week the (ECB) will step in."

Sarkozy pledged to have a revised EU treaty ready for signing by March. It would then need to be ratified in each country, which could mean lengthy parliamentary debates or national referendums in some cases.

"A lot depends on the specifics and how these are going to be framed by lawyers," said Piotr Maciej Kaczynski, an expert on EU constitutional issues at the Center for European Policy Studies in Brussels.

At the very least, it could take at least 18 months to ratify a new treaty once it has been signed by all heads of state, said Kaczynski. "That is a much longer timeline than what markets might want," he said.

Bond-market analysts said they remain skeptical of Europe's ability to prevent future profligacy. "If you say it strong enough and often enough maybe people will believe it," said Guy LeBas, chief fixed income strategist at Janney Montgomery Scott. "But I don't think the markets believe 'Merkozy' at this point."

EU governments reacted with caution.

No other EU leaders came out against the Franco-German proposals, but no strong statements in favor were immediately forthcoming. The reaction from Austrian Finance Minister Harald Waiglein was fairly typical: "There is nothing here that contradicts our position," although more details are needed, he said.

The modern EU is based on a set of treaties, dating as far back as the 1950s, when the project of consolidating the continent began. The treaties detail the rules that countries must follow and outline the mandates of institutions like the ECB. The most recent was the Lisbon Treaty, which was ratified in 2009, giving additional powers to the European Commission and European Parliament.

Sarkozy said he and Merkel would prefer that the treaty changes they're proposing be agreed to by all 27 members of the EU. But he left the door open to an agreement only among the 17 euro countries and anyone else "who wants to join us."

Sarkozy and Merkel discussed several broad changes for the EU treaty, but failed to provide much detail. The changes they outlined included:

? Introducing an automatic penalty for any government that allows its deficit to exceed 3 percent of GDP. A majority of nations would need to oppose automatic sanctions for a country to avoid them.

Governments are supposed to abide by the deficit limit under existing rules, but many, including France, have flouted it. Further, punishment only occurs after a majority of euro countries votes to impose them.

? Requiring countries to enshrine in law a promise to balance their budgets.

A key issue for the proposal's final approval will be how much flexibility countries can have to run temporary deficits during economic downturns.

? Pledging that any future bailouts would not require private bond investors to absorb a part of the costs, as was the case for the Greek bailout.

Germany had earlier insisted that Europe's permanent bailout fund would demand private investors take losses if a country in the future needs rescuing.

? Promising to not criticize or otherwise comment on the work of the ECB.

This is intended to ensure the bank's independence and its ability to act without pressure from European leaders.

Sarkozy said more details would be included in a letter sent Wednesday to European Council President Herman Van Rompuy.

After Sarkozy and Merkel spoke, stocks rose and borrowing rates for governments across Europe plunged, indicating a sharp rise in investor confidence in the continent's ability to resolve the crisis.

France's CAC-40 index climbed 1.2 percent, Germany's DAX rose 0.4 percent and markets outside of Europe also pushed higher, with the Dow Jones industrial average up 1.2 percent.

French banks, which have been hit hard this year over fears about their large exposure to the government bonds of financially weak countries like Greece, saw some of the biggest gains.

Societe Generale's stock price climbed 6.2 percent while BNP Paribas rose 4.9 percent. In Italy, shares of Unicredit rose 5.4 percent while Spain's Santander rose 3.6 percent.

Worries about the stability of the euro reached a fever pitch in recent weeks as the yields on Italy's bonds ? in a nutshell, its borrowing costs ? jumped above 7 percent. That is the level that eventually forced Greece, Ireland and Portugal to require bailouts. By comparison, bond yields in Germany, Europe's largest and most stable economy, are roughly 2 percent.

Italian and Spanish bond yields fell sharply on Monday, an indication of growing investor confidence in their financial future. The yield on Italy's benchmark 10-year bond fell from 6.65 percent to 5.93 percent.

Italy, whose government debt is equivalent to 120 percent of the country's annual economic output, needs to refinance $270 billion of its $2.6 trillion of outstanding debt by the end of April.

The size of the problems facing Italy and Spain are considered too large for the existing funds available to the European Financial Stability Facility ($590 billion) and the IMF ($389 billion.) To boost the firepower of the IMF, several economists have proposed that the ECB lend to it.

The big threat to the global financial system is that Europe's debt crisis could spiral out of control.

If governments default on their bonds, banks that own them could take a significant hit. It could become very difficult for these banks to borrow and nervous depositors could flee with their cash. In the worst case, a global financial panic could be triggered, in which banks all over are too skittish to lend to each other. That would cause a credit crunch that deprives businesses of the short-term financing they depend on for day-to-day operations.

With such fears in the air, the United States is ratcheting up its involvement.

U.S. Treasury Secretary Timothy Geithner Geithner will meet Tuesday in Germany with ECB President Mario Draghi and German Finance Minister Wolfgang Schauble. On Wednesday, he travels to France for talks with Sarkozy and the prime minister-elect of Spain, Mariano Rajoy Brey.

___

Pan Pylas in London, Sarah DiLorenzo in Paris and Raf Casert in Brussels also contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/business/*http%3A//news.yahoo.com/s/ap/20111206/ap_on_bi_ge/eu_europe_financial_crisis

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Tuesday, December 6, 2011

FDA revisits safety of newer birth control drugs

(AP) ? Birth control drugs that were heavily promoted as having fewer side effects and the ability to clear up acne and other hormonal bothers are under new scrutiny from safety regulators.

Research suggesting that newer birth control formulations are more likely to cause blood clots than older drugs has prompted the Food and Drug Administration to consider new safety measures in meetings later this week. The increased risk is slight but significant because blood clots can cause heart attacks, strokes and blockages in lungs or blood vessels, which can be fatal.

Regulators could order new warning labels on several contraceptives that gained popularity in the last decade, including Bayer's pill Yaz, which was the best-selling birth control pill in the U.S. for 2008 and 2009.

Yaz, Yasmin and similar drugs use a version of a female hormone which appears to reduce side effects found in older drugs, including bloating and mood swings.

Bayer AG spent more than $270 million on TV and magazine advertisements for Yaz between 2007 and 2010, according TNS Media Intelligence. Such big-budget campaigns are rare for birth control products. One advertisement featured young women singing the Twisted Sister anthem, "We're Not Gonna Take It," while popping balloons labeled "moodiness," ''bloating" and "acne."

Sales of Yaz have fallen since regulators forced Bayer to correct advertisements that overstated Yaz's benefits and as safety questions drew scrutiny in both the U.S. and Europe.

FDA also is reviewing research on clot risks associated with Johnson & Johnson's weekly Ortho Evra patch, which is marketed as an "option for busy women who are looking to simplify life." The drug uses a different version of the female hormone progestin than the pills under scrutiny.

Millions of women have used the products since they launched a decade ago, but recent studies comparing the medical histories of women taking the newer drugs to older ones suggest a slightly higher risk of blood clots in the legs and lungs. Last year, the U.S. market for female contraceptive drugs totaled $3.4 billion, according to IMS Health.

Sorting out the blood clot risk of birth control drugs is especially difficult because all hormone-based drugs increase the risk of clotting. Further complicating the issue is that clots can be caused by factors such as smoking, obesity or family history.

Yaz, Yasmin and other pills containing a synthetic hormone called drospirenone are the focus of a discussion Thursday. The next day's meeting focuses on the Ortho Evra patch, which uses the hormone norelgestromin.

Bayer says its studies have shown no difference in blood clot risk between its drugs and the older birth control drugs. But several large, independent studies suggest the risk with Yaz and similar medications is slightly higher. The latest analysis by the FDA estimates the risk of a blood clot with drospirenone-containing pills is 1.5-fold higher than other hormone-based contraceptives. That translates into an estimated 10 in 10,000 women on the newer drugs experiencing a blood clot, compared with 6 in 10,000 women on older contraceptives, according to the FDA.

"It's a very small percentage of patients that develop these, but it's such a serious side effect that I think doctors have to use a lot of caution," said Dr. Jennifer Wu, of Lenox Hill Hospital in New York.

Even if Yaz and other newer drugs get additional warning labels, some doctors say they don't expect to stop prescribing them. Doctors say the risk of blood clots with any birth control pill is still far lower than that associated with pregnancy and birth, when hormone levels and reduced blood flow increase clotting risk.

"At the end of the day I tell my patients the absolute risk is still very, very low compared to pregnancy and post-partum risk," said Dr. Rebecca Starck, of Cleveland Clinic's Fairview Hospital. "There are still many benefits to combination birth control pills."

The Ortho Evra patch already carries warning labels about an increased risk of blood clots compared with pills. Some, but not all, studies suggest patch users have twice the risk of clots. The FDA will try to further define that risk using the latest data.

Most birth control drugs use a combination of two female hormones, estrogen and progestin, to stop ovulation and help block sperm. But for decades many women have reported bloating and mood swings as side effects.

Introduced in 2001, Yasmin was the first birth control pill to use a new form of progestin called drospirenone, which appeared to have fewer side effects. The reformulated version of the drug, Yaz, was approved in 2006 with new claims on the label that it decreased acne and a severe type of mood disorder.

Yaz quickly grew into the best-selling birth control pill in the U.S. Sales plummeted more than 50 percent in 2010, after the company was forced to run corrective TV and magazine advertisements. Among other problems, the FDA said the company's commercials suggested Yaz could treat premenstrual syndrome when it has only been shown to decrease incidence of premenstrual dysphoric disorder, a severe mood disorder associated with major depression. Less than 8 percent of U.S. women experience the disorder, according to the National Institutes of Health.

Yaz currently ranks fourth in sales among contraceptive pills in the U.S. Last year doctors wrote roughly 13 million prescriptions for Yaz and two generic versions of the drug, according to IMS Health. Doctors prescribed the Ortho Evra patch nearly 1.6 million times.

Newer drugs like Yaz are no more effective than older pills, generally allowing one unplanned pregnancy per year for every 100 women.

"Many women will do fine on the older generation drugs, but some women will not," said Dr. Petra Casey, of the Mayo Clinic. "I think the newer drugs help many women in terms of mood and the water retention."

About 4,000 lawsuits against Bayer argue that any additional risk with the newer drugs should have been detected and emphasized to the public.

On Thursday, Cindy Rippee will tell the FDA panel about her 20-year-old daughter, Elizabeth, who died Christmas Eve 2008 when a blood clot traveled to her lung. Rippee says her daughter had been taking Yasmin for about two months.

"I really feel that if my daughter had been told about the increased risk she would have made a different decision," said Rippee, of Escondido, Calif.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2011-12-05-Birth%20Control-Safety/id-87759036ad4b46db9f4237ab4247bf51

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Possible Craigslist scam victim died months ago

FILE - In this Dec. 1, 2011 file photo, Richard Beasley, 52, appears in Summit County Common Pleas Court in Akron, Ohio, on drug charges. Summit County Prosecutor Sherri Bevan Walsh announced Monday, Dec. 5, 2011 that Beasley, suspected in a deadly scheme to rob people replying to a Craigslist job ad, will be charged with murder and attempted murder in attacks on four victims and could face the death penalty. (AP Photo/Tony Dejak, File)

FILE - In this Dec. 1, 2011 file photo, Richard Beasley, 52, appears in Summit County Common Pleas Court in Akron, Ohio, on drug charges. Summit County Prosecutor Sherri Bevan Walsh announced Monday, Dec. 5, 2011 that Beasley, suspected in a deadly scheme to rob people replying to a Craigslist job ad, will be charged with murder and attempted murder in attacks on four victims and could face the death penalty. (AP Photo/Tony Dejak, File)

(AP) ? An Ohio coroner says a man suspected of being the third fatal victim of a deadly Craigslist robbery scheme died in August, weeks before the suspected killings of two other victims.

The body of Ralph Geiger was discovered Nov. 25 in Noble County in rural southeastern Ohio during an investigation into two other deaths and the wounding of a fourth man.

Noble County Coroner Alan Spencer lists Geiger's date of death as around Aug. 9, according to a copy of Geiger's death certificate obtained Tuesday by The Associated Press.

Authorities believe the other victims were killed in October and November. They were lured by ads seeking workers that were posted on Craigslist, then killed.

Police have identified as suspects a 16-year-old high school student and a 52-year-old self-styled preacher.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2011-12-06-Craigslist-Jobseekers%20Killed/id-53d5a8ece7504756944ee847b69262f3

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Monday, December 5, 2011

Italian government approves austerity measures

In this picture taken Tuesday, Nov. 29, 2011, Italian Premier Mario Monti talks to journalistas at Chigi Palace, Premier's office, in Rome. Monti briefed political leaders Saturday, Dec. 3, 2011, on his package of austerity and economic growth measures ahead of a critical week of Italian and European decision-making to confront the continent's debt crisis. Politicians gave few details about the individual measures Monti outlined, but described them as "severe'' but necessary since Italy had put off tough economic reforms for too long. (AP Photo/Mauro Scrobogna, LaPresse) ITALY OUT

In this picture taken Tuesday, Nov. 29, 2011, Italian Premier Mario Monti talks to journalistas at Chigi Palace, Premier's office, in Rome. Monti briefed political leaders Saturday, Dec. 3, 2011, on his package of austerity and economic growth measures ahead of a critical week of Italian and European decision-making to confront the continent's debt crisis. Politicians gave few details about the individual measures Monti outlined, but described them as "severe'' but necessary since Italy had put off tough economic reforms for too long. (AP Photo/Mauro Scrobogna, LaPresse) ITALY OUT

(AP) ? Premier Mario Monti said Sunday his government of technocrats has approved a package of austerity and growth measures worth ?30 billion ($40.53 billion) to "reawaken" the Italian economy and help save the euro common currency from collapse.

The measures include immediate cuts to the costs of maintaining Italy's bulky political class as well as significant measures to fight tax evasion, Monti told a news conference following a three-hour Cabinet meeting.

As part of the political cost cuts, Monti said he would forego his salaries as premier and finance minister ? a move he said was a personal decision and not meant as an example for other ministers in the government, which was formed 2 1/2 weeks ago after Premier Silvio Berlusconi's resignation under market and political pressure.

The package also includes measures to spur growth and competition, while aiming to stamp out rampant nepotism. But it also raises the retirment age and the number of years of service to qualify for a full pension, steps strongly opposed by unions, and imposes new taxes on Italians' private wealth, including their homes, boats and luxury cars, measures that conservatives have protested.

"We gave a lot of weight to fairness, we had to distribute some of the sacrifices but we took a lot of care to distribute them in a fair way," Monti said.

Monti will outline the measures on Monday in addresses to both houses of Parliament, which must approve them. Monti said he will appeal to lawmakers' sense of responsibility.

The Berlusconi government stepped down due to its failure to get tough measures through a fractious Parliament, which remains intact, meaning fault lines could easily reopen.

"A lot depends on how well or not we explain to the citizens what we are trying to do," Monti said.

The premier, an economist who once was an EU commissioner, has been under extreme pressure to come up with speedy and credible measures that will persuade markets to stop betting against the common currency. Italian borrowing costs have spiked, which could spell disaster if Italy is unable to keep up on payments to service its enormous debt of ?1.9 trillion ($2.57 trillion), or 120 percent of its GDP.

Unlike Greece, Portugal and Ireland, which got bailouts after their borrowing rates skyrocketed, the eurozone's third-largest economy is considered to be too big to bail out. An Italian default would be disastrous for the 17-member eurozone and reverberate throughout the global economy.

Deputy Economic Minister Vittorio Grilli said the measures passed will ensure that Italy's budget will be balanced by 2013 through a 2 percent increase in value-added tax from the second half of 2012. Berlusconi's now-defunct government already raised the value-added tax from 20 percent to 21 percent as part of earlier measures.

In addition, the government adopted austerity measures worth ?20 billion and ?10 billion in measures aimed at boosting anemic Italian growth. They include pension reform, local government spending cuts, the reestablishment of a tax on a first house that was annulled by Berlusconi and new taxes on boats over 10 meters (30 feet) in length and on luxury cars, Grilli said.

At the same time, the measures will reduce the tax on the cost of employment, give fiscal breaks to companies that invest to grow their businesses and increase investments in local public transport.

Monti denied an impression that the measures mostly comprised new taxes.

"There are certainly taxes, we know that in Italy it is easier to reduce the deficit through new taxes than through cutting costs," Monti said. "But what we did, for example, in terms of rebalancing the pension goes in the right structural direction."

The government "made a particular effort to make sure that higher taxes did not affect the usual suspects," Monti said.

The premier spent the weekend briefing political parties, unions, business groups, consumer lobbies and others. Unions were particularly critical of the measures to reform the pension system, saying certain classes of workers, including those who do physical labor, shouldn't be forced to work extra years, and that women who enter the work force after raising children would have to work well into old age to meet seniority requirements.

The measures raise the pension age to 66 years for men in 2012 and for women by 2018, and also increases to 42 years and one month the years of service for a man to retire with full benefits, 41 years and one month for a woman. Labor Minister Elsa Fornero said it would be possible to retire earlier, "with a small penalty."

Fornero wiped away a tear when she said that the pension reform would require sacrifices, including a hold on inflation adjustments for larger pensions.

On the fight against tax evasion, Monti said there would be no more tax amnesties, a mechanism used frequently in the past to recover lost revenues. In addition, the measures imposed a 1.5 percent penalty on money that was repatriated in a recent scheme that allowed Italians who had concealed money abroad to repatriate it for a negligible 5 percent penalty.

The measures also limit cash transactions to payments under ?1,000 ? down from ?2,500. In Italy, paying in cash is common as a way to conceal transactions from the government and avoid paying the value-added tax.

After meeting with Monti earlier Sunday, the head of Italy's industrial lobby said that the survival of the common euro currency depends on Italy's coming up with very strong austerity and growth measures ? followed by a concerted effort at the European level so that Italian sacrifices are not in vain.

Confindustria President Emma Marcegaglia described the measures as "very heavy."

The coming days "will decided if the euro will survive or not. The first move to save the euro is in Italian hands, with a very strong measures," Marcegaglia said. The measures will be "fundamental to saving Italy and to saving the euro."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2011-12-04-Italy-Financial%20Crisis/id-233578aa83d846a1a7fc81c259bfd3cf

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Cesar Sanchez, Escaped Inmate, Found By Police In Illinois Port-A-Potty (VIDEO)

An inmate who jumped from a moving van while being taken back to prison Friday afternoon was found by police six hours after making his bold escape -- in an Illinois port-a-potty.

Cesar Sanchez, 37, was on his way to the Stateville Correctional Center in Crest Hill, Ill. following a court appearance when he somehow jumped from the prisoner transport van in southwest suburban Lockport, the Chicago Sun-Times reports.

Illinois Department of Corrections spokeswoman Sharyn Elman told the Chicago Tribune that authorities were investigating whether Sanchez, who was handcuffed and in a prison jumpsuit, kicked open the van door before jumping out.

After making his escape, Sanchez reportedly hitched a ride on a delivery truck to Rockdale, near Joliet, NBC Chicago reports. He was ultimately tracked to Waste Management facility in the area which contained several hundred portable toilets.

"As you can imagine, looking through 300 port-a-potties was going to be quite a job," Will County Sheriff Paul Kaupas told NBC Chicago.

Police did not have to open every door, however. Authorities used "infrared, heat-sensing technology attached to a helicopter" and dogs to narrow the search, the Sun-Times reports. They found the inmate inside one of the portable toilets about 8:15 p.m.

?He was in the doo-doo,? Kaupas told CBS Chicago.

Sanchez is serving a 7-year-sentence for burglary. His previous convictions include shoplifting, robbery, aggravated battery, motor vehicle theft and unlawful use of a credit card

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Source: http://www.huffingtonpost.com/2011/12/03/cesar-sanchez-escaped-inm_n_1126853.html

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Sunday, December 4, 2011

DigiTimes: Acer eyes ultrabook price drop for next year, bigger cuts coming in 2013

Having recently affirmed its commitment to the netbook, Acer is now reportedly looking to boost its ultrabook sales, with the help of a handsome price cut. Citing company president Jim Wong, DigiTimes reports that Acer will slash the price of its ultrabook offerings by as much as 20 percent next year, dropping them from around $1,000 to between $800 and $900. The cut, expected to go into effect during Q2 2012, will be followed by a subsequent reduction to $500 in 2013, when Acer expects more vendors to enter the market. The hope is that the manufacturer will be able to reclaim some of the ground it's lost to competitors in recent months, though it remains to be seen whether or not the strategy pays dividends.

DigiTimes: Acer eyes ultrabook price drop for next year, bigger cuts coming in 2013 originally appeared on Engadget on Thu, 01 Dec 2011 19:11:00 EDT. Please see our terms for use of feeds.

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Saturday, December 3, 2011

Bachmann says Gingrich has 'memory challenge'

(AP) ? Republican presidential candidate Michele Bachmann is pushing back after rival Newt Gingrich called her "factually challenged."

Campaigning Thursday in Florida, the congresswoman from Minnesota said both Gingrich and former Massachusetts Gov. Mitt Romney are guilty of changing positions when it's politically convenient. And she said Gingrich has a "memory challenge."

On Wednesday, the former House speaker and college professor said of Bachmann: "In the eyes of a teacher, occasionally I'd have a student who couldn't figure out where things were, or what things were, or what the right date was. When that happens, you feel sorry that they're so factually challenged."

Gingrich's criticism apparently refers to several instances in which Bachmann has flubbed some facts, such as when she said she would close the U.S. Embassy in Iran ? even though the U.S. hasn't had an embassy there for decades.

Bachmann said of Gingrich: "I think that a professor doesn't like to be challenged, but I think that his real challenge is a memory challenge."

Gingrich and Romney are at the top of some national polls in the race for the Republican nomination while Bachmann often appears in single digits.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2011-12-01-Bachmann-Gingrich/id-3e3e99d1f5ec42febf481c3bfdcf867a

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Bye-Bye Barney, Part II (Powerlineblog)

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Friday, December 2, 2011

First analysis of tumor-suppressor interactions with whole genome in normal human cells

First analysis of tumor-suppressor interactions with whole genome in normal human cells

Wednesday, November 30, 2011

Scientists investigating the interactions, or binding patterns, of a major tumor-suppressor protein known as p53 with the entire genome in normal human cells have turned up key differences from those observed in cancer cells. The distinct binding patterns reflect differences in the chromatin (the way DNA is packed with proteins), which may be important for understanding the function of the tumor suppressor protein in cancer cells. The study was conducted by scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory and collaborators at Cold Spring Harbor Laboratory, and is published in the December 15 issue of the journal Cell Cycle.

"No other study has shown such a dramatic difference in a tumor suppressor protein binding to DNA between normal and cancer-derived cells," said Brookhaven biologist Krassimira Botcheva, lead author on the paper. "This research makes it clear that it is essential to study p53 functions in both types of cells in the context of chromatin to gain a correct understanding of how p53 tumor suppression is affected by global epigenetic changes ? modifications to DNA or chromatin ? associated with cancer development."

Because of its key role in tumor suppression, p53 is the most studied human protein. It modulates a cell's response to a variety of stresses (nutrient starvation, oxygen level changes, DNA damage caused by chemicals or radiation) by binding to DNA and regulating the expression of an extensive network of genes. Depending on the level of DNA damage, it can activate DNA repair, stop the cells from multiplying, or cause them to self-destruct ? all of which can potentially prevent or stop tumor development. Malfunctioning p53 is a hallmark of human cancers.

Most early studies of p53 binding explored its interactions with isolated individual genes, and all whole-genome studies to date have been conducted in cancer-derived cells. This is the first study to present a high-resolution genome-wide p53-binding map for normal human cells, and to correlate those findings with the "epigenetic landscape" of the genome.

"We analyzed the p53 binding in the context of the human epigenome, by correlating the p53 binding profile we obtained in normal human cells with a published high-resolution map of DNA methylation ? a type of chemical modification that is one of the most important epigenetic modifications to DNA ? that had been generated for the same cells," Botcheva said.

Key findings

In the normal human cells, the scientists found p53 binding sites located in close proximity to genes and particularly at the sites in the genome, known as transcriptions start sites, which represent "start" signals for transcribing the genes. Though this association of binding sites with genes and transcription start sites was previously observed in studies of functional, individually analyzed binding sites, it was not seen in high-throughput whole-genome studies of cancer-derived cell lines. In those earlier studies, the identified p53 binding sites were found not close to genes, and not close to the sites in the human genome where transcription starts.

Additionally, nearly half of the newly identified p53 binding sites in the normal cells (in contrast to about five percent of the sites reported in cancer cells) reside in so-called CpG islands. These are short DNA sequences with unusually high numbers of cytosine and guanine bases (the C and G of the four-letter genetic code alphabet, consisting of A, T, C, and G). CpG islands tend to be hypo- (or under-) methylated relative to the heavily methylated mammalian genome.

"This association of binding sites with CpG islands in the normal cells is what prompted us to investigate a possible genome-wide correlation between the identified sites and the CpG methylation status," Botcheva said.

The scientists found that p53 binding sites were enriched at hypomethylated regions of the human genome, both in and outside CpG islands.

"This is an important finding because, during cancer development, many CpG islands are subjected to extensive methylation while the bulk of the genomic DNA becomes hypomethylated," Botcheva said. "These major epigenetic changes may contribute to the differences observed in the p53-binding-sites' distribution in normal and cancer cells."

The scientists say this study clearly illustrates that the genomic landscape ? the DNA modifications and the associated chromatin changes ? have a significant effect on p53 binding. Furthermore, it greatly extends the list of experimentally defined p53 binding sites and provides a general framework for investigating the interplay between transcription factor binding, tumor suppression, and epigenetic changes associated with cancer development.

This research, which was funded by the DOE Office of Science, lays groundwork for further advancing the detailed understanding of radiation effects, including low-dose radiation effects, on the human genome.

The research team also includes John Dunn and Carl Anderson of Brookhaven Lab, and Richard McCombie of Cold Spring Harbor Laboratory, where the high-throughput Illumina sequencing was done.

Methodology

The p53 binding sites were identified by a method called ChIP-seq: for chromatin immunoprecipitation (ChIP), which produces a library of DNA fragments bound by a protein of interest using immunochemistry tools, followed by massively parallel DNA sequencing (seq) for determining simultaneously millions of sequences (the order of the nucleotide bases A, T, C and G in DNA) for these fragments.

"The experiment is challenging, the data require independent experimental validation and extensive bioinformatics analysis, but it is indispensable for high-throughput genomic analyses," Botcheva said. Establishing such capability at BNL is directly related to the efforts for development of profiling technologies for evaluating the role of epigenetic modifications in modulating low-dose ionizing radiation responses and also applicable for plant epigenetic studies.

The analysis required custom-designed software developed by Brookhaven bioinformatics specialist Sean McCorkle.

"Mapping the locations of nearly 20 million sequences in the 3-billion-base human genome, identifying binding sites, and performing comparative analysis with other data sets required new programming approaches as well as parallel processing on many CPUs," McCorkle said. "The sheer volume of this data required extensive computing, a situation expected to become increasingly commonplace in biology. While this work was a sequence data-processing milestone for Brookhaven, we expect data volumes only to increase in the future, and the computing challenges to continue."

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DOE/Brookhaven National Laboratory: http://www.bnl.gov

Thanks to DOE/Brookhaven National Laboratory for this article.

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Source: http://www.labspaces.net/115583/First_analysis_of_tumor_suppressor_interactions_with_whole_genome_in_normal_human_cells_

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